Drumroll plz..... Applied Nutriceuticals RPM!!!!

[Vitruvian]

Goals.

We all have them. But what truly is a goal?

Webster’s dictionary defines a goal as:
1. The end toward which effort is directed
2. The terminal point of a race.

But when it comes to fitness and bodybuilding goals, these definitions only tell part of the story. Yes, we want to get there. But we want to get there FAST. Whether your goal is losing a few pounds, increasing strength, or bursting through a new plateau, we all want to race to our “personal finish lines” as fast as possible. Unfortunately, conflicting goals in our lives often get in the way of our fitness goals and we get sidelined from the race. Therefore we seek out products to help improve our chances of reaching our goals more quickly and easily. Unfortunately, all too often hard-earned dollars are spent on products that make great claims, only for us to be disappointed and no closer to our goals than when we started. Sound familiar?

Applied Nutriceuticals has the answer to putting you back in the driver’s seat and speeding towards your goal faster that you ever thought possible! That product is RPM™ a Phyto-Chemical Selective Androgen Re-uptake Modulator (PSARM). RPM is a breakthrough formulation that provides explosive energy, uncanny mental focus, amazing strength increases, insane pumps, suppressed estrogen, increased testosterone…all while incinerating fat! Best of all, these results are noticed from the very first dose! RPM gives the best of both worlds…instant gratification coupled with long-term results!

Let’s look at each benefit that this super-charged formula provides……………

Amazing Strength Increases
From the very first dose you will notice the RPM is much more than just another pre-workout energy formula. RPM’s unique blend of compounds combine potent testosterone boosters that will allow you to achieve your goals of size and strength faster than you ever thought possible! RPM’s amazing ingredient blueprint applies new scientific theories regarding SARMs (Selective Androgen Re-uptake Modulators) in a completely unique way; pushing RPM’s effectiveness past any other conventional testosterone booster. Building lean hard muscle tissue has never been this easy.


Increased Density and Hardness
When you work hard, you want it to show and to look our best. RPM dramatically hardens the look of your physique by reducing aromatase and estradiol. The end result is a denser, harder look with reduced water retention. Now you can finally show off the results of hours in the gym and display the lean muscle you have worked so hard for.

Uncanny Mental Focus
As you begin your warm up, any nagging thoughts cluttering your mind give way to a more purposeful, focused state of mind that allows you to concentrate on the task at hand; your workout. As your energy increases the body and mind become one allowing you to focus on your training like never before. RPM’s unique blend of cognitive and mood enhancers give you drive like no other product that helps improve every aspect of your life.

Explosive Energy
Not since the days of Ephedra has there been such a high octane formula available to rev up your workouts. Within 1 hour of the very first dose you will feel the blood flowing like never before. No longer are there any feelings of fatigue from a busy day or a poor night’s sleep.

Mind-blowing pumps
Ready for insane volume? RPM will give you pumps like never before. No, we’re not referring to the same old half-hearted pumps that quickly go away and leave you feeling deflated. We are talking true fullness and volume. RPM provides acute vasodilation action by increasing Nitric oxide thru PDE5 inhibition, leading to a stronger and much more forceful contraction. In short, RPM has a longer lasting more potent NO pump then you have ever felt before.

Incinerates FAT
RPM’s revolutionary formula is also a very potent fat burner. The thermogenic qualities of RPM are reminiscent of the old Ephedra days, without having to stack it with anything else to make it work!

Instant gratification. Log term gains. Intensity. Strength. Energy. Focus. Drive. Pump. Fat Burning. It’s all here. Your personal checkered flag has never been so close. It’s time to get in the race.

[Vitruvian]

A little more Icariin info, plus PDE5 inhibitor info- ENJOY!!

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The prerequisites of a SARM (selective androgen reuptake modulator) are the ability of a compound to: "stimulate increases in strength and fat-free mass through testosterone mimetic properties, supporting bone growth, and maintaining and restoring sexual function and general "maleness", while being orally bioavaliable and not effecting blood pressure or blood lipids." Icariin fits every one of these prerequesites, here are some studies:

Asian J Androl. 2006 Sep;8(5):601-5. Epub 2006 Jun 5.Click here to read Links
The testosterone mimetic properties of icariin.

* Zhang ZB,
* Yang QT.

Department of Urology, Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, China. zbzhang@stu.edu.cn

AIM: To evaluate the testosterone mimetic properties of icariin. METHODS: Forty-eight healthy male Sprague-Dawley rats at the age of 15 months were randomly divided into four groups with 12 rats each: the control group (C), the model group (M), the icariin group (ICA) and the testosterone group (T). The reproductive system was damaged by cyclophosphamide (intraperitoneal injection, 20 mg/kg x day) for 5 consecutive days for groups M, ICA and T, at the sixth day, ICA (gastric gavage, 200 mg/kg x day) for the ICA group and sterandryl (subcutaneous injection, 5 mg/rat . day) for the T group for 7 consecutive days, respectively. The levels of serum testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH), serum bone Gla-protein (BGP) and tartrate-resistant acid phosphatase activity in serum (StrACP) were determined. The histological changes of the testis and the penis were observed by microscope with hematoxylin-eosin (HE) staining and terminal deoxynucleotidyl transferase biotin-dUTP-X nick end labeling (TUNEL), respectively. RESULTS: (1) Icariin improved the condition of reproductive organs and increased the circulating levels of testosterone. (2) Icariin treatment also improved the steady-state serum BGP and might have promoted bone formation. At the same time, it decreased the serum levels of StrACP and might have reduced the bone resorption. (3) Icarrin suppressed the extent of apoptosis of penile cavernosal smooth muscle cells.
CONCLUSION: Icariin has testosterone mimetic properties and has therapeutic potential in the management of hypoandrogenism.


Pharmazie. 2005 Dec;60(12):939-42. Links
Icariin, a flavonoid from the herb Epimedium enhances the osteogenic differentiation of rat primary bone marrow stromal cells.Chen KM, Ge BF, Ma HP, Liu XY, Bai MH, Wang Y.
Institute of Orthopaedics, Lanzhou General Hospital, Lanzhou, Gansu 730050, PR China. Chkeming@yahoo.com.cn

The herb Epimedium has long been used in Traditional Chinese Medicine to treat bone fracture and prevent osteoporosis. Researchers believe that the flavonoids contained in the herb are the effective component for this activity. However, no single flavonoid has been studied for its effect on bone-related cells. In the present study, icariin, one of the major flavonoids of the herb, supplemented the primary culture medium of rat bone marrow stromal cells (rMSCs) at 0.1 microM , 1 microM and 10 microM respectively. It was found that icariin stimulated the proliferation of rMSCs and increased the number of CFU-F stained positive for alkaline phosphatase in a dose-dependent manner. Icariin also dose-dependently increased the alkaline phosphatase activity, osteoalcin secretion and calcium deposition level of rMSCs during osteogenic induction. The addition of 10 microM icariin caused four times more mineralized bone nodules to be formed by rMSCs than in the control. The results demonstrated that icariin should be an effective component for bone-strengthening activity, and one of the mechanisms is to stimulate the proliferation and enhance the osteogenic differentiation of MSCs.

Pharmacol Biochem Behav. 2005 Dec;82(4):686-94. Epub 2005 Dec 27. Links
Antidepressant-like effect of icariin and its possible mechanism in mice.Pan Y, Kong L, Xia X, Zhang W, Xia Z, Jiang F.
State Key Laboratory of Pharmaceutical Biotechnology, Immunobiological Laboratory, Institute of Functional Biomolecule, Nanjing University, PR China.

The behavioral, neurochemical and neuroendocrine effects of icariin isolated from Epimedium brevicornum were investigated in behavioral despair models of KunMing strain of male mice. Icariin was found to significantly shorten immobility time in the forced swimming test (FST) after orally administration for 21 consecutive days. Icarrin also produced a marked reduction in immobility time in the tail suspension test (TST) when administered for at least 7 consecutive days. The preferable antidepressant action by icariin was obtained at 17.5 and 35 mg/kg in the present study. Moreover, it was observed that the stress of FST exposure induced increases in brain monoamine oxidase (MAO) A and B activities, serum corticotropin-releasing factor (CRF) levels, as well as decreases in brain monoamine neurotransmitter levels. Treatment of icariin for 21 consecutive days mainly reversed the above effects in the mouse FST. These results suggested that icarrin possessed potent antidepressant-like properties that were mediated via neurochemical and neuroendocrine systems.

Asian J Androl. 2005 Dec;7(4):381-8. Links
Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats.Liu WJ, Xin ZC, Xin H, Yuan YM, Tian L, Guo YL.
Andrology Center of Peking University First Hospital, Beijing 100009, China.

AIM: To investigate the effect of icariin on erectile function and the expression of nitric oxide synthase (NOS) isoforms in castrated rats. METHODS: Thirty-two adult male Wistar rats were randomly divided into one sham-operated group (A) and three castrated groups (B, C and D). One week after surgery, rats were treated with normal saline (groups A and cool.gif or oral icariin (1 mg/[kg.day] for group C and 5 mg/[kg.day] for group D) for 4 weeks. One week after treatment, the erectile function of the rats was assessed by measuring intracavernosal pressure (ICP) during electrostimulation of the cavernosal nerve. The serum testosterone (ST) levels, the percent of smooth muscle (PSM) in trabecular tissue, and the expression of mRNA and proteins of neuronal nitric oxide synthase (nNOS), inducible nitric oxide synthase (iNOS), endothelial nitric oxide synthase (eNOS) and phosphodiesterase V (PDE5) in corpus cavernosum (CC) were also evaluated. RESULTS: ICP, PSM, ST and the expression of nNOS, iNOS, eNOS and PDE5 were significantly decreased in group B compared with those in group A (P 0.01). However, ICP, PSM and the expression of nNOS and iNOS were increased in groups C and D compared with those in group B (P 0.05). Changes in ST and the expression of eNOS and PDE5 were not significant (P 0.05) in groups C and D compared with those in group B. CONCLUSION: Oral treatment with icariin ( 98.6 % purity) for 4 weeks potentially improves erectile function. This effect is correlated with an increase in PSM and the expression of certain NOS in the CC of castrated rats. These results suggest that icariin may have a therapeutic effect on erectile dysfunction.

Wei Sheng Yan Jiu. 2005 Mar;34(2):191-3. Links
[Effects of Icariin on ovariectomized osteoporotic rats][Article in Chinese]
Bao JR, Yang JW, Li SF, Zhao W, Zhang Q, Yan Y.
Life Science College, Northeast Agricultural University, Harbin 150030, China.

OBJECTIVE: To observe the effects of Icariin on ovariectomized osteoporotic rats. METHODS: Female Wistar rats were ovariectomized and administered different dosage of Icariin and 17beta-estradiol for eight weeks. Bone mineral density (BMD), indexes of biomechanics and bone metabolism-associated biochemical markers were measured. RESULTS: Icariin increased the BMD, maximum load and flexural rigidity in the osteoporotic rats. The activities of serum tartrate-resistant acid phosphatase (TRACP) and bone alkaline phosphatase (BALP) were decreased in the Icraiin-fed ovariectomized rats. CONCLUSION: Icariin 225mg/kg per day could increase the BMD and improve indexes of bone biomechanics in ovariectomized osteoporotic rats. It was effective in preventing bone loss induced by ovariectomy.


Icariin fits all of the criteria for a SARM, except it is in a very well-researched phytochemical extract, not an undeveloped potential pharmaceutical drug- hence the title Phytochemical SARM (P-SARM)


I included these two because Icariin is a strong PDE5 inhibitor, just like Viagra and Cialis

Clin Endocrinol (Oxf). 2004 Sep;61(3):382-6. Links
Type V phosphodiesterase inhibitor treatments for erectile dysfunction increase testosterone levels.
Carosa E,
Martini P,
Brandetti F,
Di Stasi SM,
Lombardo F,
Lenzi A,
Jannini EA.
Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy.
OBJECTIVE: Lack of sexual activity due to erectile dysfunction (ED) decreases testosterone (T) levels through a central effect on the hypothalamic-pituitary axis. In this paper we studied the effect of different type V phosphodiesterase (PDE5) inhibitor treatments for ED on the reversibility of this endocrine pattern. DESIGN: Open-label, retrospective study. PATIENTS: Seventy-four consecutive patients were treated on demand with sildenafil (Sild) (50 mg) and tadalafil (Tad) 20 mg. MEASUREMENTS: The success in sexual intercourse was recorded and total (tT) and free testosterone (fT) levels were studied before and after 3 months of treatment. RESULTS: Basal level of tT and fT were at the bottom of the normal range and LH levels were at the top of the high normal range. After treatments, this endocrine pattern was reversed in both groups. However, the T increase in Sild-treated patients was significantly lower than in those treated with Tad (4.7 +/- 2.7 vs. 5.1 +/- 0.9, P < 0.001). fT levels followed a directly proportional pattern, while the inverse was found when LH production was studied. The intercourse rate reflected this effect: in fact, the Sild group showed a 4.9 +/- 2.9/month full sexual intercourse rate while in the Tad group a significantly higher rate of sexual intercourse was found (6.9 +/- 4.6/month, P = 0.04). However, drug consumption was comparable between the groups (Sild 4.9 +/- 2.9 vs. Tad 4.4 +/- 2.8 pills/month, P = 0.72). CONCLUSIONS: As it is unlikely that the two drugs have a different direct effect on the pituitary-testis axis, this effect is probably due to the higher frequency of full sexual intercourse in the Tad-treated group, because of the drug's longer half-life.



J Sex Med. 2006 Jul;3(4):716-22. Links
Testosterone:estradiol ratio changes associated with long-term tadalafil administration: a pilot study.
Greco EA,
Pili M,
Bruzziches R,
Corona G,
Spera G,
Aversa A.
Internal Medicine, Department of Medical Pathophysiology, University of Roma La Sapienza, Rome, Italy.
INTRODUCTION: It has been reported that lack of sexual activity due to erectile dysfunction (ED) may be associated with testosterone (T) decline. AIM: To investigate whether the known changes in sex hormones associated with resumption of sexual activity are sustained in the long term. MAIN OUTCOME MEASURES: Primary endpoints were variations from baseline of steroid hormones: total T, free T (f T), and estradiol (E). Secondary endpoints were variations of erectile function domain scores at International Index of Erectile Function-5 (IIEF-5). METHODS: In an open-label fashion, 20 patients (mean age 54.8 +/- 8.4 years) received tadalafil 10-20 mg on demand for 12 months. Exclusion criteria were those reported for phosphodiesterase inhibitors, including hypogonadism and hyperprolactinemia. RESULTS: Tadalafil assumption was safe and well tolerated (overall adverse effects in 15% of patients) and none discontinued medication. A significant decrease in E levels occurred at the end of the study (from 19.9 +/- 9.6 to 16.6 +/- 8.1 ng/dL, P = 0.042 vs. baseline), with parallel increase in the T:E ratio (26.3 +/- 15.3 to 32.6 +/- 17.7, P = 0.05), whereas no changes in T and f T serum levels were observed, respectively (411.4 +/- 131.4 to 434.2 +/- 177.1 ng/dL and 47.7 +/- 15.3 to 49.9 +/- 19.1 pmol/L, not significant). Interestingly, nonparametric subgroup analysis for related samples revealed that E decrease was detectable only in lean (N = 14) but not in obese (N = 6, body mass index > 27.5 kg/m2) subjects (17.8 +/- 10.1 vs. 13.5 +/- 6.8, P < 0.05). A net increase in IIEF-5 scores was observed at the endpoint (13.7 +/- 5.9 vs. 25.7 +/- 2.9, P < 0.0001). CONCLUSIONS: Sustained improvement in sexual function after 12 months of tadalafil administration is associated with increased T:E ratio mainly related to reduction of E levels. We hypothesize that androgen-estrogen cross-talk and possible inhibition of aromatase activity during chronic exposure to tadalafil might have a role in the regulation of erectile function.

[Vitruvian]

I'll have more for you when I get more time to post.... basically you're looking at a pre-workout test boosting, AI, N.O. boosting, cognitive stimulant. No jitters, clean energy and focus, rapid rise in test levels.... End Result: The best workouts of your life.

Not a kitchen sink formulation either..... precise blends.... it's all about effective ingredients in effective doses and ratios.


Examples: I weighed 170-something a few days ago... shoulder pressed 95 lb DB's for 5..... next day, did body weight dips for sets of 20, 30, and then 50.... before doing skullcrushers, 3 sets of 10 with 100 lbs.

I'll get you the technical writeup and FAQ's in the coming days.............

[prophet]

it intrigues me... prices?

[Vitruvian]

Originally Posted by prophet

it intrigues me... prices?

I hope to have an answer for you soon.....

I'm guessing not cheap to be 100% honest. AN didn't cut corners and go with the cheapest ingredients they could find. Example: Other companies are using 5-20% extracts of Icariin.... we went with a 50%.

BUT, not expensive either. Especially when you factor in that the budget lifter could use RPM only 1 time a day on workout days and see definite benefits. While daily use will increase benefits, awesome benefits can be had with pre-workout only dosing.

[LoveGuinness]

AN prodcuts are awesome, maybe Josh will like this one?

Awesome write up, excellent info!

[prophet]

Originally Posted by Vitruvian

I hope to have an answer for you soon.....

I'm guessing not cheap to be 100% honest. AN didn't cut corners and go with the cheapest ingredients they could find. Example: Other companies are using 5-20% extracts of Icariin.... we went with a 50%.

BUT, not expensive either. Especially when you factor in that the budget lifter could use RPM only 1 time a day on workout days and see definite benefits. While daily use will increase benefits, awesome benefits can be had with pre-workout only dosing.

*cough*discount for epoc members *cough*

[Vitruvian]

Originally Posted by prophet

*cough*discount for epoc members *cough*

Hmmm... I'll see if anything is available, but since most of our sales are through retailers, it's tough for us to control the public price. There is however a sale on our products currently at NutraPlanet... CHEAP! Not sure for how long.

How about this:
Email dirkt@bellsouth.net with your name, forum, and shipping info, and in the email, ask nicely for a sample of RPM.
Tell him Vitruvian sent you ;-)

It'll be a week or so before anything can be sent, as we blew through over 300 samples in just a couple days, and are currently packaging more. Retail release on the product is slated for early May.

[Vitruvian]

Somewhere around 2000 samples sent. That's a lot of RPM!!!!!

Available for pre-sale now! Shipped to retailers yesterday!!!!!!!!

[LoveGuinness]

awesome! hopefully you get some good reviews.

[Vitruvian]

Originally Posted by LoveGuinness

awesome! hopefully you get some good reviews.

Reviews are about 99% Great!

Sold out the ENTIRE first run in under 16 hours. :bdance